The Interleukin 1 Gene Cluster Contains a Major Susceptibility Locus for Ankylosing Spondylitis
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چکیده
منابع مشابه
The Il1 Gene Cluster Is a Major Locus Determining Susceptibility to Ankylosing Spondylitis
A.E. Timms1, A.M. Crane1, A.-.M. Sims1, H. Cordell2, L. Bradbury1, O. Beynon1, G.R. Duff5, L.R. Cardon4, A. Calin3, P. Wordsworth1 , M.A. Brown1. 1Institute of Musculoskeletal Sciences, The Botnar Research Centre, Oxford, United Kingdom; 2Cambridge Institute of Medical Research, Addenbrookes Hospital, Cambridge, United Kingdom; 3Royal National Hospital for Rheumatic Diseases, Bath, United Kingd...
متن کاملPolymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis.
Ankylosing spondylitis (AS) is a common and highly familial rheumatic disorder. The sibling recurrence risk ratio for the disease is 63 and heritability assessed in twins >90%. Although MHC genes, including HLA-B27, contribute only 20-50% of the genetic risk for the disease, no non-MHC gene has yet been convincingly demonstrated to influence either susceptibility to the disease or its phenotypi...
متن کاملInterleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in ankylosing spondylitis.
OBJECTIVE Since ulcerative colitis and Crohn's disease, which are associated with ankylosing spondylitis (AS), have been found to be variably associated with the IL-1B and the IL-1RN genes encoding interleukin-1beta (IL-1beta) and the interleukin-1 receptor antagonist (IL-1ra), we have investigated whether these polymorphisms in IL-1B and IL-1RN are also involved in AS. METHODS DNA was isolat...
متن کاملAssociation of Interleukin-10 gene polymorphisms with ankylosing spondylitis.
OBJECTIVE Genetic polymorphisms of the Interleukin-10 (IL-10) promoter have been implicated in several autoimmune diseases, including seronegative spondyloarthropathies. This study investigated whether single nucleotide polymorphisms (SNPs) and haplotypes of IL-10 are associated with ankylosing spondylitis (AS), a common subtype of spondyloarthritis (SpA). METHODS The serum levels of IL-10 we...
متن کاملUrolithiasis in ankylosing spondylitis: Correlation with Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI) and Bath ankylosing spondylitis metrology index (BASMI)
Background: Increased incidence of renal stone has been reported in ankylosing spondylitis (AS), but unlike some well-known renal involvements, they have not been fully studied. The aim of this study was to investigate the association of AS with urolithiasis and also the relation between urinary stone and severity markers. Methods: One hundred-sixty three AS patients were included in a cross-s...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2004
ISSN: 0002-9297
DOI: 10.1086/424695